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Pathway Source Integration - Selam T. Bedane

Anglų
2014-09-17
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The vigorous growing of resources for biological pathway information helps researchers in building mechanistic hypotheses of drug targets. There are numerous open and commercial pathway sources available for Drug Discovery Scientists, but since pathways are constructed abstractions, there is quite a lot of disagreement between the sources. This project aims at integration of pathway sources based on the ove ... Visas aprašymas

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The vigorous growing of resources for biological pathway information helps researchers in building mechanistic hypotheses of drug targets. There are numerous open and commercial pathway sources available for Drug Discovery Scientists, but since pathways are constructed abstractions, there is quite a lot of disagreement between the sources. This project aims at integration of pathway sources based on the overlap of member proteins and protein-protein-interactions (PPIs). The main objective is to quantify the similarity between pairs of pathways in these sources. This was done by calculating three similarity score measures i.e. the Gene Content distance, PPI distance and pathway name distance. After getting the three similarity score results, Pearsons correlation was used to identify if there was a relation between results.

Daugiau informacijos

Autorius Selam T. Bedane
Leidėjas LAP LAMBERT Academic Publishing
Išleidimo metai 2014
Viršelio tipas Minkšti viršeliai
EAN 9783659606861
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43,07 € 57,42 €